jakisoni wa Enrofloxacin

Pharmacodynamic Enrofloxacin ndi yotakata sipekitiramu bactericidal mankhwala makamaka ntchito fluoroquinolone nyama.Za e.coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest's bacteria, suppurative corynebacterium, ogonjetsa magazi pott's bacteria, staphylococcus aureus, mycoplasma, etc. ndi streptococcus ndi ofooka, ofooka mphamvu pa anaerobic mabakiteriya.Zili ndi zotsatira zoonekeratu za post-antibacterial pa mabakiteriya okhudzidwa.The antibacterial kanthu limagwirira cha mankhwala ndi ziletsa bakiteriya DNA atembenuza, kusokoneza kugawanika, transcript ndi kukonza bakiteriya DNA recombination, bakiteriya sangathe kukula ndi kubereka bwinobwino ndi kufa.

Pharmacokinetics Mankhwalawa adayamwa mwachangu komanso kwathunthu ndi jakisoni wamuscular.The bioavailability inali 91.9% mu nkhumba ndi 82% mu ng'ombe.Amagawidwa kwambiri mu nyama ndipo amatha kulowa bwino mu minofu ndi madzi amthupi.Kupatula cerebrospinal fluid, kuchuluka kwa mankhwala pafupifupi m'magulu onse ndikokwera kuposa m'madzi a m'magazi.Chachikulu kwa chiwindi kagayidwe ndi kuchotsa ethyl wa 7-piperazine mphete kupanga ciprofloxacin, kenako makutidwe ndi okosijeni ndi glucuronic asidi kumanga.Makamaka kudzera mu impso (impso tubular secretion ndi glomerular filtration) kutuluka, 15% ~ 50% mu mawonekedwe oyambirira a mkodzo.Kuthetsa theka la moyo wa jekeseni mu mnofu anali 5.9 maola ng'ombe mkaka, 1.5 ~ 4.5 maola nkhosa, ndi 4.6 maola nkhumba.